Palladium‐Catalyzed Cascade to Benzoxepins by Using Vinyl‐Substituted Donor–Acceptor Cyclopropanes
نویسندگان
چکیده
A palladium-catalyzed intermolecular cascade (4+3) cyclocondensation of salicylaldehydes and vinylcyclopropanes is reported. key feature the reaction use a phosphonate group as an acceptor moiety on cyclopropane, exploiting its propensity to undergo olefination with aldehydes. Subsequent O-allylation enabled formation range substituted benzoxepinsWith novel chiral ligand, products were obtained in generally good yield reasonable enantioselectivity.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202102862